Pre-eclampsia and Biochemical Markers

Correlation Between Complications of Pre-eclampsia and Detection of Novel Biochemical Markers

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02665897

Acronym

PET

Enrollment

Registered

2016-01-28

Start date

2016-01-31

Completion date

2017-05-31

Last updated

2017-06-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Detection of Preeclampsia Complications

Brief summary

In view of both endothelial injury in pre-eclampsia, high blood pressure and kidney impairment characteristics, a recent study demonstrated that the serum levels of NGAL increased at the end of the second trimester in women who subsequently developed pre-eclampsia compared to the control group. This correlates well with the endothelial damage that occurs during pre-eclampsia and thus NGAL can be considered as a promising marker in predicting both early and late onset pre-eclampsia. It may be required to combine one or more biomarker with NGAL to increase the precision, and sensitivity for detection of risk and reliability of using biomarkers for pre-eclampsia.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Age 20-40 years. * Gestational age \>20 weeks.

Exclusion criteria

* Patients with preexisting renal disease,hypertension, diabetes mellitus, gestational hypertension. * Patients Refuse to participate in the study * Patients already have complicated preeclampsia.

Design outcomes

Primary

Measure	Time frame
The level of circulating NGAL	24 hours

Countries

Egypt

Outcome results