Edema, Pain, Trismus
Conditions
Keywords
pain measurement, edema, trismus
Brief summary
The main aim of the study is to investigate the pre-emptive effect of dexamethasone and diclofenac associated to codeine to prevent the pain, edema and limited mouth opening at the extraction of third molar.
Detailed description
The surgery of third molar is usually associated with important post-surgical sequelae. The damage caused to tissue and bone may result in considerable pain, edema and trismus. The symptoms start gradually, peaking in 2 days after the extraction. The use of medications such as dexamethasone and diclofenac associated to codeine may support the prevention of post-surgical pain. This clinical trial aim compare the the pre-emptive effect of dexamethasone and diclofenac associated to codeine to prevent the pain, edema and limited mouth opening at the extraction of third molar.
Interventions
DRUGDexamethasone
Dexamethasone 8 mg
DRUGDiclofenac Sodium associated with Codeine
Diclofenac Sodium 50 mg associated with Codeine 50 mg
Sponsors
Federal University of the Valleys of Jequitinhonha and Mucuri
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Patients with indication of asymptomatic bilateral extractions of lower third molars; * Aged 18 years or older; * Have a good health and no disease;
Exclusion criteria
* Patients with history of any medication treatment within 15 days before the beginning of the research, history of allergy to the drugs, substances or materials used in this study, pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post-surgical swelling of third molar extraction determined using linear measures in the face | Up to seven days post-surgical | During the post-surgical intervals of 24, 48 and 72 hours and seven days, the swelling was determined using linear measures in the face. |
| Post-surgical trismus of third molar extraction determined by maximum mouth opening | Up to seven days post-surgical | During the post-surgical intervals of 24, 48 and 72 hours and seven days, the trismus was determined by maximum mouth opening. |
| Post-surgical pain of third molar extraction using visual analogic scale | Up to seven days post-surgical | The post-surgical pain was self-recorded by the patient using visual analogic scale in intervals of 24, 48 and 72 hours and seven days. |
Secondary
| Measure | Time frame |
|---|---|
| Analgesic consumption | Up to seven days post-surgical |
| Duration of surgery | Up to seven days post-surgical |
Countries
Brazil
Outcome results
None listed