Obesity
Conditions
Keywords
Obesity, Appetite regulation, Insulin sensitivity, Adolescents, Exercise
Brief summary
In obese adolescents, energy expenditure (EE) of chronic high intensity muscular exercise (\> 70% VO2max) conducted one hour before a meal causes an anorectic effect at lunch and dinner the same day. The effect on food intake of the distribution of this exercise into two sessions during 24h remains to be determined. In addition, a multidisciplinary load of obesity generates a loss of body weight in the short term, which we do not know the effects on energy balance. To our knowledge, the impact of weight loss on the anorectic effect of muscle exercise is unknown.
Detailed description
Two measuring sequences will be carried out before (M0) and after 4 months (M4) of a multidisciplinary treatment program of four months. Each sequence will have three days: a sedentary day (SED) and two days exercise (EX). During the exercise day EX1, a continuous intense exercise will be conducted for 40 min at 70% VO2max of subjects. During the second day exercise EX2 teenage realize two exercise representing the same DE as EX1 in the morning (50% ED) and late afternoon (50% ED). The multidisciplinary management program (without energy restriction) controlled by institution consists of nutrition education, physical activity and therapeutic education. The exercise program will involve the activity sessions controlled and supervised by a sports educator and interactive sessions using a scientifically validated physical activity program (Biomouv®).
Interventions
BEHAVIORALPhysical activity
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
12 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Overweight adolescents (over the 90 th percentile of the international cut-off point) * Sedentary (according to the IPAQ-A questionnaire) * Without eating disorders (according to the DEBQ questionnaire)
Exclusion criteria
* Medical or surgical antecedents that are incompatible with the study: cardiovascular, endocrine or digestive disease. * Drugs that could interfere with the results of the study * Surgical intervention in the 3 months * Regular consumption of tobacco or Alcohol * patients on a diet with caloric restriction * Refusal to sign the consent form * Regular practice of sport and intensive
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison between(M0) and (M4) of food intake on 24 hours (total and per meal) | after 4 months of physical activity | Comparison between(M0) and (M4) of food intake on 24 hours (total and per meal) assessed during a day with the completion of intense exercise performed in one session EX1, in two sessions (EX2) or sedentary (without exercise: SED). The exercise-induced energy expenditure by 40 minutes at 70% of VO2 max is the same in EX1 and EX2. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison between(M0) and (M4) of the Flint scale | after 4 months of physical activity | Comparison between(M0) and (M4) of the Flint scale (feeling of hunger, desire to eat, the feeling of being full) |
| Comparison between(M0) and (M4) of the Pittsburg scale | after 4 months of physical activity | — |
| Comparison between(M0) and (M4) of HOMA-IR | after 4 months of physical activity | Comparison between(M0) and (M4) of HOMA-IR by measuring the blood glucose and fasting insulin |
| Comparison between(M0) and (M4) of Fitness | after 4 months of physical activity | Comparison between(M0) and (M4) of Fitness (by VO2 max and estimated body composition). |
Countries
France
Outcome results
None listed