Contrast-induced Nephropathy: Incidence,Risk Factors,Effective Prevention and Management Method

Chinese People's Liberation Army General Hospital

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02664246

Enrollment

10000

Registered

2016-01-27

Start date

2015-01-31

Completion date

2016-01-31

Last updated

2016-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardio-Renal Syndrome

Keywords

contrast-induced nephropathy, Percutaneous coronary intervention, risk factors, incidence

Brief summary

This review article have included about ten thousand patients undergoing percutaneous coronary intervention (PCI), aim to identify the incidence of CIN in actual, find some new risk factors and the protecting methods for these factors.

Detailed description

About ten thousand patients undergoing percutaneous coronary intervention (PCI) from 2010 to 2015 are included in this study. We collect the data about the SCr of the patients before and after percutaneous coronary intervention, and define CIN as an increase in SCr of 0.5 mg/dl or 25% from baseline between 48 and 72 h after contrast medium exposure. Besides we obtain the data including clinical characteristics, laboratory data (blood and urine tests) for all the patients. The statistical analysis will find some new risk factors.

Interventions

DEVICEpercutaneous coronary intervention

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

1. congestive heart failure: objective evidences for decreased left ventricular eject fraction (LVEF) \<= 50%; 2. moderate to severe chronic kidney disease was defined as an eGFR 15 to 59 mL/min per 1.73 m2, calculated via the abbreviated Modification of Diet in Renal Disease (MDRD) study equation from SCr obtained within 72 hours of enrollment; 3. patients were scheduled to undergo diagnostic cardiac angiography or percutaneous coronary interventions.

Exclusion criteria

1. hemodialysis-dependent patients; 2. complicated with severe short-term progressive disease; 3. Patients \< 18 years; 4. pregnancy; 5. emergency cardiac catheterisation (eg, primary percutaneous coronary intervention for ST-segment elevation myocardial infarction); 6. exposure to radiographic contrast media within the previous 7 days; 7. acute decompensated heart failure.

Design outcomes

Primary

Measure	Time frame	Description
Contrast induced nephropathy postoperation	7 days	peak serum creatinine increase of either 0.5 mg/dl or 25% from day 0 through day 7

Secondary

Measure	Time frame	Description
Composite measure of dialysis or main cardiovascular events	90 days	dialysis, myocardial infarction, heart failure and all-cause death

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026