Epigenetic Mechanisms and Severe Obesity (Biological Tissue Collection)

Conditions

Diabetes, Metabolic Diseases, Non-alcoholic Fatty Liver Disease, Obesity

Brief summary

The purpose of this study was to evaluate the role of vitamin status and epigenetic mechanisms on severe obesity related-complications.

Nicodème Chabi, Claire Nominé-Criqui, Almut Heinken, Didier Quilliot, Laurent Brunaud et al. (11 authors)

Nutrients2026-04-01

10.3390/nu18071137

Medium term post-bariatric surgery deficit of vitamin B12 is predicted by deficit at time of surgery.

Antoine D, Li Z, Quilliot D, Sirveaux MA, Meyre D, Mangeon A, Brunaud L, Guéant JL, Guéant-Rodriguez RM.

2020-04-254 citations

10.1016/j.clnu.2020.04.029

Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity.

Li Z, Gueant-Rodriguez RM, Quilliot D, Sirveaux MA, Meyre D, Gueant JL, Brunaud L.

2017-07-2475 citations

10.1016/j.clnu.2017.07.008

Interventions

PROCEDUREgastric bypass, sleeve, gastric banding

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* indication for bariatric surgery with BMI \> 35 kg/m2

Exclusion criteria

* unable to receive clear information * refusal to sign the consent form

Design outcomes

Primary

Measure	Time frame
Evaluation of folate mediated one-carbon metabolic pathway parameters (Folates, Vitamin B12, Methionine, Homocysteine) on severe obesity-related complications before and after bariatric surgery	10 years

Secondary

Measure	Time frame
Evaluation of DNA Methylation on severe obesity-related complications before and after bariatric surgery	10 years

Countries

France

Contacts

Primary ContactLaurent BRUNAUD, MD, PhD

l.brunaud@chu-nancy.fr

Outcome results

None listed