Lactation
Conditions
Keywords
Neurotrophins, Stem Cells, Prematurity
Brief summary
Human breast milk contains growth factors including neurotrophins and cells with neuroprotective potential. Concerning growth factors milk of preterms differs significantly from term milk. The aim of this study is to give a profile of human milk concerning non-nutritive factors depending on gestational age and lactation phase.
Detailed description
Neurotrophins (epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), nerve growth factor (NGF), brain derived neurotrophic factor (BDNF)) as well as amount of cells, especially positive for sex-determining transformer protein (TRA)-1-81 and stage-specific embryonic antigen (SSEA)-4, are planned to be quantified in human breast milk of extremely preterm newborns as well as term newborns at different stages of lactation.
Interventions
None listed
Sponsors
University Hospital of Cologne
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* the newborn infant is being fed with own mothers milk
Exclusion criteria
* low amount of breast milk
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| neurotrophins composition | day 7 | Concentration of Neurotrophins EGF, VEGF, NGF, BDNF in the human milk |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Amount of cells positive for surface markers TRA-1-81 and SSEA-4 | day 7 | surface markers characteristic for pluripotent stem cells |
Countries
Germany
Outcome results
None listed