Infertility
Conditions
Brief summary
Successful embryo implantation needs an optimum embryonic development with a receptive endometrium. Endometrial thickness is an independant factor for endometrial receiptivity. The aim of that trial is to assess the benefecial effect of platelt rich plasma in copmarison with standard hormonal therapy.
Detailed description
This is a single blinded randomized trial comparing the effect of of platlet rich plasma versus hormonal therapy on endometrial thickness and consequently endometrial receptivity. The primary endpoint of this trial is clinical pregnancy rate.
Interventions
BIOLOGICALplatlet rich plasma
Platelet-rich plasma (PRP) is prepared from fresh whole blood which is collected from a peripheral vein, stored in acid citrate dextrose solution A (ACD-A) anticoagulant and processed to increase platelets by separating various components of blood
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* patients undergoing ICSI * endometrial thickness less than 7 mm on early follicular phase
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| endometrial thickness in mm | 72 hours | using transvaginal ultrasound to measure endometrial thickness in mm |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| clinical pregnancy rate | 4 weeks after embryo transfer | using transvaginal ultrasound to detect fetal cardiac activity |
Countries
Egypt
Contacts
Primary Contactrasha Dr medhat, MD
Backup Contactahmed DR kotb, MD
Outcome results
None listed