Invitro Fertilization
Conditions
Keywords
ICSI, endometrial injury, implantation rate
Brief summary
Midluteal single endometrial strip will be taken using a Novak curett under general anasthesia to avoid discomfort and cramping and to proceed to cervical dilatation in case of forbidden cervix, the step that will be beneficial to embryo transfer procedure. Controller ovarian hyperstimulation; will be done using the long luteal phase agonist protocol and the short protocol(as judged by patient,s age ovarian reserve judged by day 3 FSH and antral follicular count and previous history of ovarian response). Ovarian response will be monitored by vaginal ultrasound and HCG will be given when when there is \>=1 follicle \>=18 mm. and \>=3 follicles \>=16 mm. Ultasound guided oocyte retrieval will be carried out 35 hours later. Embryo transfer will be performed on day 2 or day 3 after oocyt retrieval according to number and quality of embryos. Embryo transfer will be carried out under trans-abdominal ultrasound guidance pregnancy test will be done using qualitative blood HCG detection 2 weeks after the embryo transfer.
Interventions
PROCEDUREEndometrial scratch injury
midluteal single endometrial strip will be taken using a Novak curett under general anasthesia to avoid discomfort and cramping and to proceed to cervical dilatation in case of forbidden cervix
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
1. subfertile women indicated for ICSI. 2. normal uterine cavity demonstrated by transvaginal ultrasound and hystrogram. 3. FSH\<10mIU/mL on day 3 of her cycle.
Exclusion criteria
1. presence of endometrial polyp or fibroid distorting the uterine cavity. 2. hydrosalpinx. 3. ICSI carried out for preimplantation genetic diagnosis. 4. FSH\>10mIU\\mL.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| implantation rate | 14 days after embryo transfer | number of sacs identifiable through ultrasonography divided by the number of embryos transferred |
| clinical pregnancy rate | 4 weeks after embryo transfer | the detection of fetal cardiac activity within a gestational sac on ultrasonography examination |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| multiple pregnancy rate | 4 weeks after embryo transfer | number of patients who had a multifetal pregnancy divided by the total number of clinical pregnancies |
| abortion rate | 12 weeks of gestational age | number of patients who had a spontaneous abortion before 12 weeks of pregnancy divided by total number of clinical pregnancies |
Countries
Egypt
Outcome results
None listed