Autism Spectrum Disorder, Obsessive Compulsive Disorder
Conditions
Brief summary
The aim of this study is to test the feasibility and acceptability of an internet-delivered cognitive behavior therapy (ICBT) intervention originally developed for neurotypical adolescents with obsessive compulsive disorder (OCD) in adolescents with OCD and autism spectrum disorder (ASD). This feasibility study will inform us how to adapt the original intervention to the specific needs of patients with ASD.
Detailed description
To evaluate the effectiveness of ICBT for OCD in adolescents with ASD, this study will use a single case experimental design with weekly measures during two phases: A-B. The A-phase will consist of baseline measures at least three weeks prior to treatment. The B-phase will consist of the 12 weeks ICBT-program as well as one measure post-treatment. Single case descriptions of each participant will be presented. Weekly measures on the Obsessional Compulsive Inventory - Child version (OCI-CV) will be analyzed through visual inspection of each participants graph and through computation of Percentage of Non-overlapping Data (PND). PND is a frequently used effect measure in SCED and reflects how large percentage of the measurements during the treatment-phase that do not overlap with any of the measurements during the base-line phase. To assess the feasibility and comprehension of the ICBT treatment semi-structured interviews (face-to-face or telephone) will be conducted with participants and parents weekly during the four first weeks of ICBT and semi-weekly during the rest of the treatment. Detailed notes will be taken during each interview and will serve as content material for a thematic analysis trying to determine possible accommodations to the ICBT protocol to better suit patients with ASD.
Interventions
The treatment consists of standard cognitive behavior therapy for obsessive-compulsive disorder and is delivered via an internet platform and regular therapist contact several times per week via email and telephone. The treatment is 12 weeks. Both parents and adolescents are involved in treatment. Parents will also receive three lectures on 1, Autism spectrum disorder, 2, CBT and functional analysis and 3, Parental strategies
Sponsors
Karolinska Institutet
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
12 Years to 17 Years
Healthy volunteers
Yes
Inclusion criteria
* a diagnosis of OCD as defined by DSM-5 \[40\] * a diagnosis of autism defined by DSM-5 * a total score of ≥ 16 on the Children's Yale-Brown Obsessive-Compulsive Scale, CY-BOCS \[14\] * age between 12 and 17 years * ability to read and write Swedish * access to the internet * a parent that is able to co-participate in the treatment * Participants on psychotropic medication must have been on a stable dose for the last 6 weeks prior to baseline assessment
Exclusion criteria
* psychosis or bipolar disorder, severe eating disorder * suicidal ideation * subject not able to read or understand the basics of the ICBT material * completed CBT for OCD within last 12 months (defined as at least 5 sessions of CBT including exposure and response prevention) * ongoing psychological treatment for OCD or another anxiety disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Obsessional Compulsive Inventory - Child version, OCI-CV | Change from baseline to 12 weeks | Self-rated OCD symptom levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mini International Neuropsychiatric Interview for Children and Adolescents, MINI-KID | Baseline | psychiatric screening of comorbidity |
| Clinical Global Impression - Severity, CGI-S | Change from baseline to 12 weeks | Global symptom levels |
| Clinical Global Impression - Improvement, CGI-I | Post treatment(12 weeks) | Global symptom improvement |
| Children's Global Assessment Scale, CGAS | Change from baseline to 12 weeks | Global level of functioning |
| Children's Yale Brown Obsessive Compulsive Scale | Change from baseline to 12 weeks | Clinician-rated OCD symptom levels |
| Strength and difficulties, SDQ | Change from baseline to 12 weeks | General psychopathology |
| Family Accommodation Scale, Parent-Report, FAS-PR | Change from baseline to 12 weeks | Parental accommodation to OCD symptoms |
| Patient ICBT Adherence Rating, PIAR | after 6 weeks and at post treatment(12 weeks) | Patient Adherence to internet delivered CBT |
| Education, Work and Social Adjustment Scale - child and parent version, EWSAS | Change from baseline to 12 weeks | Global functioning |
| Children´s Depression Inventory - Short version | Change from baseline to 12 weeks | Symptom level of depressive mood |
Countries
Sweden
Outcome results
None listed