Mortality in Cancer Patients Admitted to the Intensive Care Unit in a Resource-limited Setting

Mortality in Cancer Patients Admitted to the Intensive Care Unit in a Resource-limited Setting: A Prospective Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02659839

Enrollment

142

Registered

2016-01-20

Start date

2015-07-31

Completion date

2016-10-31

Last updated

2016-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer

Keywords

Cancer, Intensive care unit, Mortality

Brief summary

The purpose of this study is to determine 30 day mortality in cancer patients admitted to the intensive care unit in a resource limited setting.

Detailed description

The management of cancer patients in the intensive care unit (ICU) has changed dramatically during the last two decades. Initial experiences showed high rates of hospital mortality, reaching up to 75-85% in patients requiring life-sustaining treatments, particularly mechanical ventilation. An increasing number of clinical experiences has been reported pointing to a significant improvement in survival of these patients. However, it is not clear if this results are generalizable to settings with resource constraints. Therefore, the purpose of this study is to determine 30 day mortality in cancer patients admitted to the intensive care unit in a resource limited setting. This study is a prospective cohort of cancer patients admitted to the ICU in which the investigators will evaluate the prognostic of cancer patients admitted for a ICU trial or treatment in ICU without limitations. This study will not consider any change in the treatment plan of the patients. The source of the data will be the clinical records of the patients during the admission and the records of the cancer unit. There will be no direct contact of the research team with the patients or their family.

Interventions

OTHERCancer patients admitted to the ICU

There will be no change in the standard ICU treatment.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 18 years-old or older * Histological diagnosis or high clinical suspicious of cancer (solid /hematological), with the exception of non-melanoma skin cancer. * Functional classification state between 0-3, according to Eastern Cooperative Oncology Group. * Admission to intensive care unit, because of one or more of the following criteria: 1. Invasive or non-invasive ventilatory support due to acute respiratory failure. 2. Use of vasopressor drugs due to hypotension defined as noradrenaline requirement higher than 0.1 microgram/Kg/min. 3. Renal replacement therapy due to acute renal failure.

Exclusion criteria

* Absence of cancer recurrences in more than 5 years after diagnosis * Functional classification state of 4, according to Eastern Cooperative Oncology Group.

Design outcomes

Primary

Measure	Time frame
Mortality at 30 days	30 days since ICU admission

Secondary

Measure	Time frame
Mortality at 180 days	180 days since ICU admission

Countries

Chile

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026