Anesthesia
Conditions
Brief summary
Rocuronium block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. There have been several studies reported positive relationship between muscle mass and amount of neuromuscular junction. The purpose of this study is to find 50% effective dose and 95% effective dose of rocuronium according to muscle mass.
Detailed description
Rocuronium block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. There have been several studies reported positive relationship between muscle mass and amount of neuromuscular junction. Until now, dose of rocuronium has been judged by patient's weight and height. When the rocuronium was developed, 50% effective dose and 95% effective dose of rocuronium was calculated by patient corrected body weight which used weight and height. However, height and weight do not represent exact muscle mass. The purpose of this study is to find 50% effective dose and 95% effective dose of rocuronium according to muscle mass. Measurement of muscle mass will be obtained using bioelectrical impedence analysis.
Interventions
DEVICEInbody
Participant measure muscle mass by bioelectrical impedance analysis (Inbody 720, Inbody, Seoul, Korea) after fast for eight hours.
DRUGRocuronium
The individual dose method was used for the determination of the dose response of rocuronium. After induction of anesthesia, four groups of 40 patients each received randomly one of the four doses of rocuronium ( 0.24, 0.32, 0.40, 0.48mg/muscle mass(kg))
Sponsors
Go Eun Bae
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
19 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
* All patient who undergo general anesthesia
Exclusion criteria
* Liver and kidney disease * Any types of muscle disorder. * Metal materials or pacemaker in body
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| percentage of neuromuscular block | ten minutes | percentage of neuromuscular block is calculated by ratio of T1 to T4. T1 is result of first stimulation and T4 is result of fourth stimulation which are obtained by commonly used neuromuscular monitoring device. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| onset time | ten minutes | time from the end of injection of rocuronium until the maximal depression of T1 which is result of first twitch |
Other
| Measure | Time frame | Description |
|---|---|---|
| lag time | ten minutes | time from the end of injection of rocuronium until the first depression of the twitch response |
Countries
South Korea
Contacts
Primary ContactGo eun Bae, M.D.
Outcome results
None listed