Bronchiectasis
Conditions
Keywords
Bronchiectasis, High-intensity inspiratory muscle training
Brief summary
Reduced exercise tolerance is commonly reported in patients with bronchiectasis. The purpose of this study is to evaluate the effects of high-intensity inspiratory muscle training (High-IMT) and sham High-IMT (control) on exercise capacity, respiratory muscle function (strength and endurance) and health related quality of life in patients with bronchiectasis.
Detailed description
Bronchiectasis often demonstrates decreased exercise tolerance, marked dyspnea and fatigue. The causes are multifactorial and include altered pulmonary mechanics, inefficient gas exchange, decreased muscle mass, and psychological status, which all lead to a progressive detraining effect. Essentially both the pathology and the functional manifestations of bronchiectasis increase the demand for inspiratory muscle work and that contribute to dyspnea and exercise limitation. In recent studies reduced strength of respiratory muscles are investigated in bronchiectasis and can be contribute the exercise limitation. Additionally IMT has shown to improve respiratory muscle function, exercise tolerance and dyspnea in patients with bronchiectasis. Despite this, the number of studies are inadequate and so the optimal training protocol remains still to be defined. In this study the researchers want to investigate the effects of high-intensity inspiratory muscle training in functional results in patients with bronchiectasis.
Interventions
Sponsors
Hacettepe University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* diagnosis of bronchiectasis with high resolution computed tomography * being 18-65 years of age * being able to walk and co-operate
Exclusion criteria
* acute exacerbation or change in drugs or usage of antibiotics in last 3 weeks * neurological disease, severe orthopaedic problem or advanced heart failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exercise capacity using incremental shuttle walk test and 6-minute walk test | Baseline to 8 weeks | * The incremental shuttle walk test will be performed in an enclosed corridor. Patients are required to walk back and forth, turning around two cones placed 9 meters apart making the shuttle distance 10 meters long. Patients will follow the rhythm dictated by the audio signal. * 6-minute walk test will be performed in a long, straight, enclosed corridor 30 meters in length. Patients are required to walk in their walking speed with standardised instructions. The distance walked by subjects during 6 minutes will be recorded. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory muscle endurance | Baseline to 8 weeks | Respiratory muscle endurance is assessed with constant and progressive loading protocols which subjects breathe against threshold loads. |
| Health related quality of life is assessed with Leicester Cough Questionnaire | Baseline to 8 weeks | — |
| Respiratory muscle strength | Baseline to 8 weeks | Respiratory muscle strength is measured through maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) using a handheld device. |
| Fatigue severity is assessed with Fatigue Severity Index | Baseline to 8 weeks | — |
| Severity of disease is assessed with Bronchiectasis Severity Index | Baseline to 8 weeks | — |
| Dyspnea severity is assessed with The Modified Medical Research Council Dyspnea Scale (MMRC) | Baseline to 8 weeks | — |
Countries
Turkey (Türkiye)
Outcome results
None listed