Human Papillomavirus
Conditions
Keywords
Human Papillomavirus, oropharynx biopsy, tonsillar lesion
Brief summary
Multicentre prospective study of concordance between two tissue sampling modes (smear / biopsy), which applies the same diagnostic method (PCR).
Interventions
PROCEDURETonsil Biopsy
Biopsies were obtained during endoscopy of Aero-Digestive Tract Superior under general anesthesia.
PROCEDURESmear
The smears are made in consultation a fortnight before performing endoscopic examination. They are carried out after a local anesthetic spray in order to optimize the number of cells collected.
Sponsors
University Hospital, Toulouse
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Presents a suspicious lesion of the amygdala region * Have a biopsy of the oropharynx planned in the operating room.
Exclusion criteria
* Pregnant Patient. * Against anesthetic or surgical indication for endoscopy of the upper aerodigestive tract.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the correlation between the two sampling methods | 1 month | the correlation between the two sampling methods (smear and biopsy), defined by the probability of positive correlation and the negative concordance probability. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| rate of concordance for the detection of HPV between biopsy and smear | 1 month | — |
| the overall agreement | 1 month | the overall agreement, assessed by kappa Cohen. |
Countries
France
Outcome results
None listed