Brain Tumor, Brain Lesion
Conditions
Keywords
Functional Ultrasound, Intraoperative, Brain, Doppler, Ultrasound
Brief summary
A wide spectrum of methods is used to image brain activation in vivo. It can be directly detected by neurons electrical activity imaging (cortical simulation mapping, calcium imaging, voltage sensitive dyes) or indirectly by imaging hemodynamic changes induced by the neurovascular coupling in the vessels surrounding the activated neurons (intrinsic optical imaging, photoacoustic imaging, positron emission tomography (PET), functional magnetic resonance imaging (fMRI)). Ultrasound as the potential to complement these functional imaging techniques at low cost. Ultrasound imaging can do real-time in-depth imaging of brain. However, its use to imaging of major vessels has been limited until now due to its poor sensitivity. To overcome this limitation functional ultrasound (fUS) was developed in Institut Langevin since 2011. This technique enables high spatio-temporal resolution imaging of whole-brain microvasculature dynamics in response to brain activation without the need of contrast agent. This fUS method relies on a new power Doppler imaging sequence sensitive enough to detect blood flow in most of cerebral vessels (arterioles, big venules and larger vessels). Repeating the acquisition of such ultrasensitive Doppler images over time enables to follow flow dynamics in such vessels modulated by local neuronal activity. Applied to the rat brain, fUS was proved able to map brain activation at high spatiotemporal resolution and high signal to noise ratio. The aim of this study is now to apply fUS on human brain in intraoperative condition. The main objective of this study is to find activation maps through intraoperative ultrasensitive Doppler compared to gold standard cortical simulation mapping and functional MRI. Secondly the investigators want to test sensitivity of this new Doppler mode. fUS method will be used for different types of stimuli and intensity and the investigators will do some control acquisitions. Blood vessel density observed with a conventional Doppler will be compared to the one measured with the ultrasensitive Doppler to prove that this new Doppler mode enhance micro vessel visualization.
Interventions
DEVICEUltrasound device
Ultrasensitive Doppler acquisition obtained with the Aixplorer ultrasound device
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Men and women, adults ( \> 18 years old) * Participants who have to undergo brain surgery, awake or under general anesthesia, for tumor or lesion resection (all types of tumors and lesions, cortical or subcortical), with programmed intraoperative ultrasound and cortical simulation mapping. * Consent form signed by the patient after being informed (written and oral) of the research protocol. * Patient affiliate to the social welfare system
Exclusion criteria
* Minors ( \< 18 years old) * Pregnant, parturient or breastfeeding women * Protected persons, under guardianship, or under any administrative or legal right and liberty revocation procedure * Patient without affiliation to the social welfare system
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Activation maps through intraoperative ultrasensitive Doppler compared to gold standards cortical simulation mapping and functional MRI | During the surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity test of the new Doppler mode | During surgery | fUS method will be tested for different types of stimuli and intensity and the investigators will do some control acquisitions. |
| In depth micro vessel localization | During surgery | Blood vessel density observed with a conventional Doppler will be compared to the one measured with the ultrasensitive Doppler. |
Countries
France
Outcome results
None listed