Mechanical Ventilation Complication
Conditions
Keywords
Diaphragm, Ventilators, Mechanical
Brief summary
We will investigate whether measurement of the change in thickness of the diaphragm during the respiratory cycle by ultrasound can predict extubation success in a 48 hour window. We will also asses whether this is only possible on low levels of pressure support as has been shown previously, or if this technique retains its predictive power at higher levels of pressure support.
Interventions
PROCEDUREDiaphragm Ultrasound
Once on a pressure support weaning trial, enrolled subjects will have an ultrasound of their right hemidiaphragm performed on three levels of pressure support: 15/5 10/5 and 5/5
Sponsors
Albert Einstein Healthcare Network
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age greater than 18, ventilated for \>24 hours
Exclusion criteria
* already chronically on mechanical ventilatory support, already has tracheostomy, has pathology that obscures visualization of the right hemidiaphragm, has acute stroke either hemorrhagic or ischemic, cannot identify appropriate decision maker to get informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Extubation Success | 48 hours | Discontinuation from mechanical ventilation in 48 hours from ultrasound PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Re-intubation | 48 hours from removal of ventilatory support | Reinstitution of mechanical ventilation within 48 hours of extubation PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available. |
Countries
United States
Participant flow
Recruitment details
0 participants analyzed. PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available.
Pre-assignment details
0 participants analyzed. PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available.
Participants by arm
| Arm | Count |
|---|---|
| Main Cohort all patients enrolled will have an ultrasound of their diaphragm performed once they are on a pressure support trial. Intervention: Diaphragm Ultrasound
Diaphragm Ultrasound: Once on a pressure support weaning trial, enrolled subjects will have an ultrasound of their right hemidiaphragm performed on three levels of pressure support: 15/5 10/5 and 5/5
PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available. | 0 |
| Total | 0 |
Baseline characteristics
| Characteristic | — |
|---|---|
| Region of Enrollment United States | — participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 0 |
| other Total, other adverse events | 0 / 0 |
| serious Total, serious adverse events | 0 / 0 |
Outcome results
Primary
Extubation Success
Discontinuation from mechanical ventilation in 48 hours from ultrasound PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available.
Time frame: 48 hours
Population: PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available.
Secondary
Re-intubation
Reinstitution of mechanical ventilation within 48 hours of extubation PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available.
Time frame: 48 hours from removal of ventilatory support