Bipolar Disorder
Conditions
Brief summary
The overall goal of this study is to employ diffusion-weighted imaging (DWI) and tractography to investigate differences in connectivity in the rostral dorsal cingulum bundle (CB) in patients with bipolar disorder type I (BDI) or bipolar type II (BDII) compared to matched controls, and to utilize this information to determine if high-frequency deep brain stimulation (DBS) of the rostral dorsal CB has realistic potential as a therapy for producing mood stabilization in patients with BDI or BDII.
Interventions
OTHERMagnetic Resonance Imaging
Sponsors
National Institutes of Health (NIH)
University Hospitals Cleveland Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Inclusion and
Exclusion criteria
for Group 1: Healthy Volunteers a. Inclusion Criteria for Group 1: i. Male or female, age 18 or older ii. In the opinion of the investigator, capable of understanding and complying with protocol requirements iii. In the opinion of the investigator, has the competency to understand and sign the informed consent iv. Physically healthy v. Without any current and/or lifetime psychiatric disorder assessed with a Structured Clinical Interview for psychiatric Disorders, including the Mini International Neuropsychiatric Interview (MINI) b.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences in connectivity in the rostral dorsal CB in patients with BDI or or BDII compared to matched controls | Day 1 | The imaging visit will consist of an MRI with diffusion-weighted imaging (DWI) sequences |
Countries
United States
Outcome results
None listed