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Use of Normal Saline With or Without Dextrose During Induction of Labor in Nulliparous

Utilisation parentérale de Normal Salin Avec ou Sans Dextrose Durant l'Induction du Travail Chez Les Nullipares

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02655783
Acronym
DEXTRONS
Enrollment
200
Registered
2016-01-14
Start date
2013-01-31
Completion date
2016-09-30
Last updated
2016-10-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delivery Uterine

Keywords

induction of labor

Brief summary

The objective of this study is to compare the effects of use of normal saline (250 cc / h), with or without dextrose supplement, on the evolution of labor in nulliparous.

Detailed description

There is some controversy regarding intravenous hydration of patients during labor. While the use of a fast flow of hydration appears to be recognized beneficial, the addition of glucose is less well accepted. However studies on exercise physiology clearly demonstrates improved performance of skeletal muscle by increased hydration and carbohydrate replacement during prolonged exercise. This situation is similar to the condition of the uterus in labor especially since it is now established that glucose represents its principal source of energy. However, the effect of an additional carbohydrate intake on the evolution of labor has not been extensively studied until now, and there are several schools of thought on this subject. While some studies show that such glucose addition could reduce the total duration of labor as well as its second stage, others claim that this glucose supplement offers no benefit and may even be harmful to the fetus. It therefore seems imperative to conduct a study to compare the use of hydration with normal saline with or without dextrose during labor, as recommended in current flow (250 cc / h). To our knowledge, this has never been done.

Interventions

women with an elective induction of labor receive IV hydratation (250 ml/h) with a normal saline solution + 5% dextrose

OTHERnormal saline

women with an elective induction of labor receive IV hydratation (250 ml/h) with a normal saline solution

Sponsors

Université de Sherbrooke
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* nulliparous woman * monofetal pregnancy * delivery at term * elective induction * favorable cervix (Bishop score of at least 6) * cephalic presentation

Exclusion criteria

* diabetes * preeclampsia * maternal heart disease

Design outcomes

Primary

MeasureTime frame
2nd stage of laborduring delivery of a first baby, for an average of 5 hours

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026