Acute Coronary Syndrome
Conditions
Keywords
ACS, Non obstructive coronary atherosclerosis
Brief summary
The purpose of the study is to assess short and long term outcomes of acute coronary syndrome in patients with non obstructive coronary atherosclerosis, to optimize the algorithm for diagnosis and to evaluate its effectiveness
Detailed description
The study non randomized, opened, controlled. Cardiovascular Magnetic - resonance imaging reveals both ischemic and non-ischemic causes of acute coronary syndrome. Currently, it is the best method for Imaging and damage assessment of myocardial viability in coronary atherosclerosis and noncoronary injuries (V.Yu.Usov 2012). Taking into account the results of previous (D. Kawecki, B. Morawiec, P. Monney, 2015) research, it can be concluded that the introduction of cardiovascular magnetic resonance imaging into routine practice will change the structure of morbidity among patients with acute coronary syndrome and non obstructive coronary atherosclerosis . The research was conducted on small groups of patients, and therefore further data acquisition is required. It is planned to study 200 patients with acute coronary syndrome. On admission, they will receive the standard treatment of ACS with and without ST elevation. Within 72 hours they will performed diagnostic coronary angiography. If in case of non stenotic atherosclerosis of coronary artery (normal / stenosis \< 50%) patients are planned for cardiac contrast MRI, which will identify both ischemic and non-ischemic causes of acute coronary syndrome. At 30 days, 6 months, 12 months the researchers will assess the clinical condition of the patients, perform cardiac ultrasound for the evaluation of myocardial contractile function, evaluate the incidence rate of secondary endpoints
Interventions
OTHERPatients with ACS
Cardiovascular magnetic resonance (CMR) imaging with contrast (Gadovist) in regime inversion recovery time, regime T-2 weighted images , T1-weighted images.
DEVICEMRI
Sponsors
Russian Academy of Medical Sciences
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* age ≥ 18 years at time of randomization (18 years and older) * acute coronary syndrome * no obstructive coronary atherosclerosis (normal coronary artety/ plaques \<50%) is based on the results of coronary angiography for 3 days of admission * written the informed consent to participate in research
Exclusion criteria
* patients previously undergone endovascular / surgical revascularization of coronary artery * severe comorbidity * Contacts/Locations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of inflammatory infiltrate, ischemia, infarction in the myocardial tissue | 14 days after ACS |
| Left ventricular ejection fraction (Echo) | 14 days after ACS |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of myocarditis | 14 days after ACS |
| Incidence of the mortality | 6 month and 12 month after ACS |
| Incidence of the recurrent myocardial infarction | 6 month and 12 month after ACS |
| Incidence of unstable angina | 14 days after ACS |
| Incidence of the stroke | 6 month and 12 month after ACS |
| Incidence of the acute myocardial infarction | 14 days after ACS |
| Incidence of the heart failure | 6 month and 12 month after ACS |
| Incidence of Takotsubo syndrome | 14 days after ACS |
Countries
Russia
Contacts
Primary ContactVyacheslav Ryabov, MD,PhD
Backup ContactSayana Gomboeva, MD
Outcome results
None listed