Variations of the Lung Compliance During Extracorporeal Circulation and Post Operative Pulmonary Complications

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02654600

Acronym

COMPLI

Enrollment

Registered

2016-01-13

Start date

2014-06-30

Completion date

2016-06-30

Last updated

2017-05-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiopulmonary Bypass, Thoracic Surgery

Keywords

cardiac surgery, thoracopulmonary compliance

Brief summary

the decrease in thoracopulmonary compliance after cardiac surgery is well known . The investigators hypothesize that the major factor determining pulmonary outcome after cardiac surgery is the alteration of pulmonary compliance during cardiopulmonary bypass(CBP) and that this alteration is due to CBP itself through pulmonary blood emptying.

Detailed description

compliance is the compliance calculate when thorax is closed, the pulmonary compliance is the compliance calculated when thorax is opened After operation chest X-ray are daily done and blood samples as needed. Were recorded death, time of extubation,duration of non invasive ventilation,of Intensive Care Unit stay and of total hospital stay, troponin peak, lactates, blood gases, ionogram and count.Variations of compliance is analyzed through one factor paired Anova or Wilcoxon paired test. Decrease of compliance and respiratory complications are analyzed through binomial logistic regression.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* scheduled for standard aortic * mitral or coronary surgery

Exclusion criteria

* emergency operation * no complete preoperative echocardiography * surgery needing multiple table position changes * unstable cardiac or respiratory condition * difficult patient needing multiple care and/or special attention

Design outcomes

Primary

Measure	Time frame	Description
pulmonary compliance during cardiac surgery	intraoperative	compliance is calculated by dividing tidal volume (ml) by the difference between plateau-inspiratory pressure (mmHg) and end-expiratory pressure (mmHg) before ,during and after CBP

Secondary

Measure	Time frame	Description
pulmonary complications including death after cardiac surgery	1 month	intersticial and/or alveolar pulmonary oedema leading to death or extra hospital stay
thoracopulmonary compliance during cardiac surgery	intraoperative	compliance is calculated by dividing tidal volume (ml) by the difference between peak-inspiratory pressure (mmHg) and end-expiratory pressure (mmHg) before ,during and after CBP

Countries

France

Outcome results