Persistent Atrial Fibrillation
Conditions
Keywords
Persistent atrial fibrillation, catheter ablation, outcome
Brief summary
This is a prospective randomized controlled trial that compares the conventional stepwise approach with a new sequential substrate ablation approach for persistent atrial fibrillation.
Detailed description
A total number of 100 patients with persistent AF were randomized to receive either conventional stepwise ablation (conventional group) or a sequential substrate ablation (substrate group), both with the endpoint of AF termination. All patients were in AF before the procedure. The sequential substrate ablation consisted of pulmonary vein isolation (PVI) followed by cardioversion and linear ablation at the mitral isthmus, left atrial roof and cavotricuspid isthmus in order to modify the AF substrate. After achievement of bidirectional block, AF was re-induced and electrogram-based ablation was performed to achieve AF termination to sinus rhythm (SR). Endpoints are single-procedure outcome and total amount of RF ablation time required to terminate AF by electrogram-guided ablation.
Interventions
PROCEDUREAblation
In both arms, patients will undergo an ablation procedure for persistent atrial fibrillation. The sequence of ablation steps are different between both arms.
Sponsors
Johannes Gutenberg University Mainz
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* persistent atrial fibrillation lasting longer than 3 months * no previous ablations * at least 1 electrical cardioversion
Exclusion criteria
* non-persistent atrial fibrillation * previous ablation procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patients without any arrhythmias during follow-up of 12 months | 12 months |
Countries
Germany
Outcome results
None listed