MRSA/ MSSA Colonization of the Nares
Conditions
Brief summary
To determine if routinely available 10% povidone-iodine swabs are more effective than saline and 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP for decolonizing MRSA.
Interventions
DRUGSaline
DRUGPovidone-Iodine
DRUG5% Povidone-Iodine USP swabs
Sponsors
Rothman Institute Orthopaedics
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. All potential total hip and total knee arthroplasty candidates 2. All femoroacetabular osteoplasty patients 3. All pelvic acetabular osteotomy patients 4. All core decompression patients
Exclusion criteria
1. Any trauma patients 2. Any tumor patients 3. Any patient with periprosthetic joint infection 4. Any patient with surgical site infection 5. Any patient with known MRSA infection 6. Any patients allergic to povidone-iodine 7. Patients with thyroid disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MSSA/MRSA colonization in the nares | 4 hours | Subjects will undergo a swab of their nares to undergo PCR analysis to determine if they are effectively decolonized four hours after initial treatment |
| MSSA/MRSA colonization as tested by PCR | 24 hours | Subjects will undergo a swab of their nares to undergo PCR analysis to determine if they are effectively decolonized four hours after initial treatment |
Outcome results
None listed