Chronic Obstructive Pulmonary Disease
Conditions
Keywords
Respiration, Artificial, weaning, critical care
Brief summary
This study will evaluate the effect of a fully closed loop ventilation mode (Intellivent ASV) on the duration of ventilation compared to conventional modes in COPD patients.
Detailed description
COPD patients often need invasive mechanical ventilation and due to the difficulties in the weaning of these patients, duration of mechanical ventilation can be relatively longer when compared with other ICU patients. Automated systems show promising results in shortening the weaning time in some patient groups. The aim of this study is to evaluate the effect of Intellivent-ASV with Quickwean function on the total duration of invasive mechanical ventilation as a primary outcome. Secondary outcomes are success rate and duration of weaning, ventilator free days at day 28 and intubation free days at day 28 (including NIV) when compared to conventional ventilation with t-piece weaning.
Interventions
DEVICEIntellivent ASV
Automated Invasive mechanical ventilation and weaning strategy
Sponsors
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* COPD patients intubated and mechanically ventilated for less than 24 hours (Including patients who received NIV before intubation) * Age \> 18 years * Written and/or informed consent
Exclusion criteria
* Septic shock * Tracheostomy and/or home mechanical ventilation * Expected poor short term prognosis * Cardiac arrest with a poor neurological prognosis * ARDS * Broncho-pleural fistula
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Duration of intubation | 24th month | Time from intubation until extubation |
| Duration of mechanical ventilation (NIV included) | 24th month | Total time patient remains on mechanical ventilation support (invasive or noninvasive) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of manual settings | 24th month | Number of adjusments made manually to set the ventilator |
| Number of blood gas analysis tests | 24th month | Number of arterial blood gas tests under mechanical ventilation |
| Weaning duration | 24th month | Time from the beginning of weaning until extubation |
| Time spent on spontaneous ventilation | 24th month | Time patient actively triggers the ventilator |
Countries
Turkey (Türkiye)
Outcome results
None listed