Endometriosis and Brominated Flame Retardant (ENDOTOX Study)

Looking for a Link Between Endometriosis and Exposure to Lipophilic Environmental Chemicals Like Brominated Flame Retardant (ENDOTOX Study)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02651077

Acronym

ENDOTOX

Enrollment

Registered

2016-01-08

Start date

2013-11-30

Completion date

2014-11-30

Last updated

2016-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometriosis

Keywords

Endometriosis, chemical contaminants, BFRs

Brief summary

The investigators wish to highlight, in a Case-Control design, if there is an increased concentration of BFRs in omental adipose tissue of cases ( women with severe endometriosis with surgical indication ) versus bioaccumulation recorded in a control cohort ( women recruited in obstetrics and gynecology or visceral surgery showing no sign of endometriosis ) . Pairing will be operate on Age (+/- 5 years compared to the case ) , BMI ( BMI 5 Classes described by the HAS) and previous breastfeeding experience (yes / no , opposite the release expected bioaccumulate contaminants in breast adipose tissue , when the lactation ) .

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

Inclusion criterion for de cases : * Age : 18-45 years old * Deep endometriosis with or without endometriomas that need surgery (clinical examination, MRI, surgery) * Accessing to the omental and/or parietal adipose tissue * Non opposition of the patients for the samples collection and consent for the present study. Inclusion criterion for the controls : * Patients without any history of endometriosis and without suggestive symptomatology. Often patients operated for cesarean section. * Possible access to the adipose tissue of the omentum or abdominal wall Exclusion criterion for the cases : * Pregnancy * Death Exclusion criterion for controls : * Pregnancy * Death

Design outcomes

Primary

Measure	Time frame
Concentrations of brominated flame retardant (BFR) in adipose tissue and serum	baseline

Secondary

Measure	Time frame
Concentrations of dioxins in adipose tissue and serum	baseline
Concentrations of polychlorinated biphenyls (PCBs),	baseline
Concentrations of organochlorine pesticides (OCPs) in adipose tissue and serum	baseline

Countries

France

Outcome results