Infant, Premature
Conditions
Brief summary
Colostrum is the first milk secreted by the mother when the tight junctions of mammary epithelium open, allowing the cellular transport of a multitude of components and immunological protective derivatives of the maternal circulation to the milk, and especially immunoglobulins A type. Colostrum is not given to preterm neonates. The assumption behind this work is that the oro pharyngeal administration of colostrum early in preterm infants could help deliver an oral immunotherapy even before the installation of enteral nutrition, through interactions with lymphoid tissues of the oropharynx and the gastrointestinal tract. This practice would improve the digestive tolerance and the establishment of enteral feeding, the decrease in mucosal inflammatory phenomena, but also to provide any protection against subsequent infections. Finally, there could be an improvement in the secondary immune tolerance with a decrease in the occurrence of allergic phenomena.
Interventions
BIOLOGICALColostrum feeding
BIOLOGICALformula for preterm infants
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* New premature infant with a term weight ≤ 32 weeks amenorrhea at Nice University Hospital * Mother seronegative for HIV
Exclusion criteria
* Neonates with congenital pathologies immediate prenatal or neonatal diagnosis will not be included. * Therapy of the mother incompatible with breastfeeding during pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measuring caloric intake (number of days required for the calorie intake) | 2 days | number of days required for the calorie intake to 130 kcal / kg / day can be delivered exclusively enterally |
Countries
France
Outcome results
None listed