Diagnosis of Macrophage Coronary Plaque by Optical Tomographic Imaging

Diagnosis of Macrophage Coronary Plaque by Optical Tomographic Imaging : A Comparative Study With Coronary Artery of the Transplanted or Autopsy Heart

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02649881

Acronym

OCT pathology

Enrollment

Registered

2016-01-08

Start date

2015-05-12

Completion date

2017-08-31

Last updated

2018-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerotic Plaque

Keywords

macrophage, vulnerable coronary plaque

Brief summary

This study evaluated optimal macrophage diagnosis algorithm through comparative analysis between coronary artery, OCT image, and IVUS, and improve a diagnosis rate of vulnerable coronary plaque accompanied with macrophage infiltration.

Interventions

PROCEDUREThe heart subject will undergo OCT

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age 18 and above * Patients who are to receive heart transplantation * Patients or their legal representatives who gave a prior written consent

Exclusion criteria

* Impossible to OCT and IVUS analysis due to severe coronary stenosis

Design outcomes

Primary

Measure	Time frame	Description
ROC curve of diagnosis	within 48 hours	Receiver Operating Characteristic curve of diagnosis through existing NSD(normalized standard deviation)-based method and developed algorithm in the diagnosis of coronary plaque accompanied with macrophage infiltration

Secondary

Measure	Time frame
fibrin accumulation	within 48 hours
neoatherosclerosis	within 48 hours
elastic lamia	within 48 hours
cholesterol crystal	within 48 hours
microcalcification	within 48 hours

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026