Anesthesia, Pain
Conditions
Brief summary
The aim of the study was to describe the relationship between the intensity of a standardized tetanic stimulation and the associated reflex pupillary dilation in patients under ketamine sedation. After an intravenous bolus of 1 mg/kg of ketamine, tetanic stimulations were performed every minute at increasing intensities of 10, 20, 30, 40 and 60 milliamps (similar to the stimulations of neuromuscular blocking agents monitoring). Pupillary diameter was measured before and after each stimulation.
Interventions
DRUGketamine
bolus 1 mg/kg
PROCEDURETetanic stimulations of incremental intensities
10-20-30-40-60 milliamps on the patient's left forearm
Sponsors
Pr Isabelle CONSTANT
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Patient admitted to pediatric burns care unit * Burnt skin area 5-40% * Scheduled for a dressing change under ketamine sedation
Exclusion criteria
* Neurologic or ophthalmic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pupillary dilation: difference between post- and pre-stimulation pupillary diameter assessed by videopupillometry | 30 seconds after each stimulation (6 stimulations per patient) | Non-invasive measurement of pupillary diameter using an infrared camera, for each of the 6 stimulations per patient |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate variation | 30 seconds after each stimulation |
Countries
France
Outcome results
None listed