Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia

Status

Terminated

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02647892

Enrollment

Registered

2016-01-06

Start date

2016-01-08

Completion date

2021-11-05

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Local Anesthesia

Brief summary

The purpose of this study is to determine the optimal amount of lidocaine buffering needed to decrease injection pain when administering local anesthesia.

Detailed description

Once the site is chosen, the skin will be anesthetized as usual. This study will utilize a commercially prepared 1% lidocaine solution mixed with standard sodium bicarbonate. A total of 10 mL will be used.

Interventions

DRUGlidocaine

local anesthesia

DRUGsodium bicarbonate

additional drug added to lidocaine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

19 Years to 100 Years

Healthy volunteers

Inclusion criteria

* adults presenting for routine thyroid biopsy, paracentesis or thoracentesis in interventional radiology

Exclusion criteria

* Patients requiring sedation * Patients with altered mental status * Children * Patients allergic to lidocaine or sodium bicarbonate

Design outcomes

Primary

Measure	Time frame	Description
Injection pain	6 months	numeric pain scale

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026