Copeptin Blood Values
Conditions
Brief summary
Kinetics of Copeptin in response to osmotic alterations in healthy volunteers
Detailed description
Construction of the standard area of copeptin release in the normo- and hyperosmolar state and its half-life based on ist decline during hypoosmotic Suppression in healthy volunteers.
Interventions
Sponsors
University Hospital, Basel, Switzerland
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Minimum Age 18 * no severe comorbidities * no medication (except contraceptives) * baseline sodium Level 135-145mmol/l * euvolemic status
Exclusion criteria
* history of heart failure * liver cirrhosis * kidney disease (GFR \<60ml/min) * anemia * uncontrolled Hypertension * pregnancy * Diabetes mellitus * BMI \>28kg/m2 * other severe disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Physiological relationship between Serum osmolality and Plasma copeptin release. | beginning and end of protocol, up to 8 hours | Copeptin and Blood osmolality will be measured concomitantly while hypertonic saline is infused. The infusion is continued until a hyperosmolar state is reached (defined with a sodium-level of 150mmol/l). Definition of an area of normality describing the physiological relationship between Serum osmolality and Plasma copeptin release in normo- to hyperosmolar states. |
| Half life of Copeptin | beginning and end of protocol, up to 8 hours | Calculation of Copeptin half-life based on its decline during hypoosmotic suppression (oral waterload and glucose 5%-infusion) |
Countries
Germany, Switzerland
Outcome results
None listed