Taste Preferences for Nutritive and Non Nutritive Sweeteners Among Children and Adults

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02646956

Acronym

TNNS

Enrollment

Registered

2016-01-06

Start date

2014-05-31

Completion date

2015-09-30

Last updated

2016-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Development

Keywords

Sweet Taste, Psychophysics, Genetics, Diet, Age, Nonnutritive Sweetener

Brief summary

The goal of the study is to determine whether there are age-, diet- and genetically-related differences in the perception of sweeteners, both nutritive and non-nutritive.

Detailed description

This is an observational 3-day study of children between the ages of 7 and 14 and their mothers. A variety of psychophysical methods determined liking for each of the sweeteners and saliva samples were obtained for genotyping of taste receptor genes. Anthropometric and dietary intake measures were also collected.

Interventions

OTHERsweeteners

Participants tasted a variety of nutritive and nonnutritive sweeteners

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

7 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy

Exclusion criteria

* Allergies and taking medication that affected taste

Design outcomes

Primary

Measure	Time frame
Liking for the taste of sweeteners measured via the 3-point facial hedonic scale.	Through study completion, an average of 6 months.
Liking for the taste of sweeteners measured via the 5-point facial hedonic scale	Through study completion, an average of 6 months.
Liking for the taste of sweeteners measured via the Monell forced-choice, paired-comparison tracking procedure.	Through study completion, an average of 6 months.

Secondary

Measure	Time frame	Description
Genotyping of taste receptor genes via saliva donation	Through study completion, an average of 6 months	Genotyping will be completed to measure associations between individual taste receptor genotypes and liking of sweeteners.
BMI calculated from body weight and height measures	Through study completion, an average of 6 months	BMI will be calculated to examine associations between this measure and liking for sweeteners.
One day dietary intake collected via the Automated Self-Administered 24-hour dietary recall (ASA24).	Through study completion, an average of 6 months	Dietary recall will be completed to examine associations between added sugar intake and liking for sweeteners.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026