Inguinal Hernia
Conditions
Brief summary
Rocuronium is suitable for rapid induction within 60-90 seconds and its effect last 24-40 minute after single bolus injection. For outpatient surgery with short operation time, low dose rocuronium is frequently used for rapid recovery at the expense of compromised intubating condition. For better intubating condition, ketamine can be used. However, appropriate dose of ketamine with low dose rocuronium is not established yet. This study, 3 different doses of ketamine with low dose rocuronium will be compared for appropriate intubating condition.
Interventions
DRUGRocuronium
Low dose rocuronium (0.3 mg/kg) will be injected after induction of anesthesia with ketamine.
DRUGketamine 1
ketamine 1 mg/kg will be injected for induction of anesthesia
DRUGketamine 1.5
ketamine 1.5 mg/kg will be injected for induction of anesthesia
DRUGketamine 2
ketamine 2 mg/kg will be injected for induction of anesthesia
Sponsors
Ajou University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
2 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* ASA class I, II
Exclusion criteria
* upper respiratory infection within 14 days * anticipated difficult intubation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intubation Condition | during and after intubation, about 2 minute | 5 variables will be individually evaluated though 3 point scale (excellent, good, poor). If all variables are graded as excellent, intubation condition will be excellent. If at least 1 variable is poor, it will be reported as poor. Otherwise, it will be reported as good. 1. Laryngoscope easiness 2. Vocal cord position 3. Vocal cord movement 4. Movement of limb 5. Coughing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| time for extubation | from the end of surgery to extubation, within 10 min | — |
| emergence agitation (4 points scale) | 5 min after postanesthesia care unit (PACU) admission | 4 points scale 1: calm 2. cry but manageable 3. cry, not manageable 4. excitation |
| PACU time | from PACU admission to discharge, about 30 min | — |
| severity of vomiting | 1. 1 min after PACU admission 2. 30 min after PACU admission | severity(0-10) |
| heart rate | 1. 1 min before induction 2.1 min after ketamine injection 3. 1min after intubation 4. 5 min after intubation 5. 10 min after intubation | heart rate will be recorded. |
| Desaturation | during PACU stay, about 30 min | pulseoximeter will be applied and peripheral oxygen saturation less than 94 will be recorded. |
| blood pressure | 1. 1 min before induction 2.1 min after ketamine injection 3. 1min after intubation 4. 5 min after intubation 5. 10 min after intubation | blood pressure will be recorded |
| frequency of vomiting | 1. 1 min after PACU admission 2. 30 min after PACU admission | — |
| Analgesic requirements (mg/kg) | during PACU stay, about 30 min | if pain score exceed 3, fentanyl will be introduced. The total dose of fentanyl injection will be recorded. |
Contacts
Primary ContactGo Un Roh, MD
Outcome results
None listed