Neuroendocrine Tumors
Conditions
Brief summary
In an individual cancer patient extensive genetic and phenotypic variation exists between and within tumor lesions. Tumour load in NET patients can be measured with fluorine-18-L-dihydroxyphenylalaninepositron emission tomography (18F-DOPA-PET) scan. This aim of the study is to investigate heterogeneity between tumor lesions within patients with intestinal NET by determining the differences in tracer uptake measured on a 18F- DOPA-PET scan retrospectively.
Detailed description
In an individual cancer patient extensive genetic and phenotypic variation exists between and within tumor lesions. Tumour load in NET patients can be measured with fluorine-18-L-dihydroxyphenylalanine positron emission tomography (18F-DOPA-PET) scan. This aim of the study is to investigate heterogeneity between tumor lesions within patients with intestinal NET by determining the differences in tracer uptake measured on a 18F- DOPA-PET scan in retrospect.
Interventions
OTHERMetastasized intestinal NET
This is an observational study
Sponsors
University Medical Center Groningen
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age ≥18 years * diagnosis of intestinal NET diagnosed by a dedicated NET specialist * more than one positive lesion on the 18F-DOPA-PET scan. * available CT-scan within 6 months before or after the 18F-DOPA-PET-scan.
Exclusion criteria
* no clinical data available at the UMCG, besides the results of the DOPA PET scan.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| tracer uptake in tumor lesions within patients with intestinal NET | at the day of scan | The difference in tracer uptake of tumor lesions within patients with intestinal NET measured on a 18F- DOPA-PET scan. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| tracer uptake in tumor lesions within patients with intestinal NET adjusted for uptake of background organ | at the day of scan | The difference in tracer uptake of tumor lesions adjusted for uptake of background organ within patients with intestinal NET measured on a 18F- DOPA-PET scan. |
Other
| Measure | Time frame | Description |
|---|---|---|
| the correlation of the magnitude of heterogeneity with ki 67 | date of diagnosis until date of scan | the correlation of the magnitude of heterogeneity between tumor lesions within patients with Intestinal NET, with the ki67 index of the tumor |
Countries
Netherlands
Outcome results
None listed