Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir With and Without Ribavirin in Protease-Inhibitors (PI) Failures

Hepatitis C

Hepatitis C Virus, Triple Therapy, PI Failure, Genotype 1

The purpose of this study is to evaluate the efficacy and safety of triple therapy of AbbVie adults with chronic hepatitis C virus (HCV), who have not responded to prior treatment with protease inhibitors. The Triple therapy of AbbVie attacks various sites of the viral genome, thus increasing the potential efficacy of the treatment, especially for patients who have failed PI treatment.

Patients with genotype 1 HCV, who underwent past triple therapy (Telaprevir, Boceprevir or Simeprevir with Pegylated interferon / Ribavirin) and are non-responders, partial responders or in relapse - will be screened in all research centers up to 30 days before the first treatment. At the end of the initial assessment - the recruited participants will be allocated to different treatment groups in accordance with the hepatitis virus subtype 1a, 1b and presence of cirrhosis, as follows: * Group A - genotype 1b without cirrhosis - 12 weeks of treatment \* * Group B - genotype 1b with cirrhosis - 12 weeks of treatment * Group C - genotype 1a without cirrhosis - 12 weeks of treatment * Group D - genotype 1a with cirrhosis - 24 weeks of treatment (\* Only this group will not get Ribavirin) During the treatment period, participants will be asked to describe the treatment's tolerability (in terms of side effects) using self-administered questionnaires: SF-36, and WPAI Hep C v2.0. The follow up will also include physical assessments, side effects documentation, blood tests, abdominal Ultrasound and Fibroscan.