ARDS
Conditions
Keywords
ARDS, Nucleotide polymorphism
Brief summary
Acute respiratory distress syndrome (ARDS) is characterized by increased pulmonary vascular permeability and reduced aerated lung tissue. With an extremely high hospital mortality among 35 - 46%, current therapeutic strategies to increase ARDS survival are still limited. Advances in etiology and pathology of ARDS are urging. Numerous genetic variants were identified associated with ARDS outcome. By whole-exome sequencing association study, our goal was to explore the associations between genetic variants and ARDS outcome.
Detailed description
Acute respiratory distress syndrome (ARDS) is characterized by increased pulmonary vascular permeability and reduced aerated lung tissue. With an extremely high hospital mortality among 35 - 46%, current therapeutic strategies to increase ARDS survival are still limited. Advances in etiology and pathology of ARDS are urging. Numerous genetic variants were identified associated with ARDS outcome. Then a few genetic risk factors have been discovered by large-scale genotyping approaches, from in vivo or in vitro models of lung injury, which highlight the importance of identifying genetic biomarkers of ARDS outcome to further improve stratification. The mutational landscape and variability at single nucleotide polymorphisms (SNP) with ARDS outcome in Chinese is unknown, not to mention their associations. By whole-exome sequencing association study, our goal was to explore the associations between genetic variants and ARDS outcome.
Interventions
OTHERBaseline-recorded data recorded
Baseline-recorded data recorded. Peripheral blood samples were drawn.
Sponsors
Southeast University, China
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Adult ARDS (according to Berlin definition) patients were enrolled in the trial. The diagnostic criteria included 1. within one week of a known clinical insult or new or worsening respiratory symptoms; 2. chest imaging showing that bilateral opacities-not fully explained by effusions, lobar/lung collapse, or nodules; 3. respiratory failure not fully explained by cardiac failure or fluid overload; 4. arterial partial pressure of oxygen / fraction of inspiration oxygen (PaO2/FiO2 ratio, P/F ratio) less than or equal to 300 mmHg.
Exclusion criteria
Patients refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of survived participants | through study completion, an average of 28 day | Survivors and non-survivors in ICU |
Countries
China
Outcome results
None listed