Effect of Dexmedetomidine on Postoperative Cognitive Function in Patients Undergoing Shoulder Arthroscopy With Beach Chair Position Under Desflurane Anesthesia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02643017

Enrollment

Registered

2015-12-30

Start date

2015-12-11

Completion date

2018-08-16

Last updated

2019-01-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rotator Cuff Tear

Keywords

cognitive function, desflurane, dexmedetomidine

Brief summary

Investigate the effects of dexmedetomidine on postoperative cognitive function in patients undergoing shoulder arthroscopy with beach chair position under desflurane anesthesia.

Interventions

DRUGDexmedetomidine

Administration of dexmedetomidine at a rate 0.6 ug/kg/hr during surgery.

DRUGnormal saline

Administration of same amount of dexmedetomidine at a rate 0.6 ug/kg/hr during surgery.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

1\. Patients undergoing shoulder arthroscopic surgery with beach chair position

Exclusion criteria

1. Patients with respiratory disease 2. Patients with cardiac disease 3. Patients with cerebrovascular disease 4. patients with uncontrolled hypertension 5. Patients with dementia 6. Patients with psychiatric disease

Design outcomes

Primary

Measure	Time frame	Description
Number of patients with postoperative cognitive decline assessed by mini-mental state examination	from 1 day before surgery to postoperative 1 day	to compare cognitive decline after surgery between control and dexmedetomidine group with mini-mental state examination.
Number of patients with postoperative cognitive decline assessed by a battery of psychometric test	from 1 day before surgery to postoperative 1 day	to compare cognitive decline after surgery between control and dexmedetomidine group with a battery of psychometric test. The battery consists of copy geometric form test, two-dimensional model test, grooved pegboard test, colored block design test, puzzle test, clock drawing test.

Secondary

Measure	Time frame	Description
Number of patients with increase of S100ß protein after surgery assessed by ELISA assay with blood of patients	from 5 min after induction of anesthesia to an 1 hour after surgery	S100ß protein is the biologic marker for neuroinflammation

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026