Liver Cirrhosis
Conditions
Brief summary
\- Cyclobenzaprine, is a muscle relaxer medication used to relieve skeletal muscle spasms. It is one of the best-studied drug for this application.
Detailed description
Although a number of mechanisms for cramps in liver disease have been postulated and have been targeted by medical therapies, a clear picture of the causal events has not emerged. Several agents as vitamin E, human albumin, zinc, taurine, eperisone hydrochloride and branched-chain amino acids have shown some benefit in small uncontrolled studies, although large randomized controlled trials are lacking. \- Cyclobenzaprine, is a muscle relaxer medication used to relieve skeletal muscle spasms. It is one of the best-studied drug for this application.
Interventions
DRUGCyclobenzaprine
cyclobenzaprine administration for 2 weeks
DRUGCalcium Carbonate
Calcium carbonate for 2 weeks
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Liver cirrhosis and has frequent muscle cramps
Exclusion criteria
* Allergy to cyclobenzaprine * Encephalopathy. * Receiving antidepressant drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of muscle cramps | 3 months | The number of muscle cramps |
Countries
Egypt
Contacts
Primary ContactSherief M. Abd-Elsalam, Consultant
Outcome results
None listed