Acute Kidney Injury, Arthroplasty, Replacement, Knee
Conditions
Keywords
total knee arthroplasty, Kidney function, Renal markers
Brief summary
Sensitive renal markers have been studied abundantly in connection with open heart, liver and transplantation surgery; however in major orthopaedic surgery their use is anecdotal. The aim of the present study is to evaluate use of sensitive renal markers, NGAL (Neutrophil gelatinase associated lipocalin ), KIM-1 (Kidney injury molecule- 1), LFABP (liver-type fatty acid-binding protein), and IL-18 (interleukin -18), in patients coming for elective TKA (total knee arthroplasty) as a pilot study before large study concerning acute kidney injury in orthopaedic surgery.
Detailed description
Acute renal deterioration is a serious adverse event in elective surgery. Serum creatinine based diagnostics of acute kidney injury may delay diagnosis and produce false negative results since serum creatinine is affected by diet, muscle mass, used hydration therapy. In recent times new markers have been developed and tested in order to find sensitive, fast and reliable marker of renal deterioration.
Interventions
None listed
Sponsors
Kuopio University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* informed consent * allergy to NSAIDs
Exclusion criteria
* no informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Renal function | time zero hours to 48 hours | S-creatinine, Cystatin C, estimated GFR |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Concentraton of sensitive renal markers | time zero hours to 24 hours | U-NGAL, P-NGAL, U-KIM-1, U-IL-18 |
Countries
Finland
Outcome results
None listed