Obesity
Conditions
Brief summary
The present study aims at evaluating the effect of two innovative treatment strategies in obese patients: high intensity interval training and hypoxic conditioning. Obese patients will be randomized in groups performing high intensity interval training, constant load training, hypoxic conditioning or placebo normoxic conditioning for 8 weeks. The effects of the interventions will be measured regarding exercise tolerance, blood pressure, body composition, metabolic status.
Detailed description
120 obese patients will be randomized to 6 intervention groups. Each group will follow an 8-week intervention (3 session per week) with either high intensity interval training in normoxia or hypoxia, constant load exercise training in normoxia or hypoxia, hypoxic or normoxic (placebo) conditioning at rest. Exercise capacity, metabolic status, blood pressure, vascular function and physical activity will be assessed before and after the intervention.
Interventions
OTHERHigh intensity interval training N
Exercise training and ambient air breathing
OTHERHigh intensity interval training H
Exercise training and hypoxic breathing
OTHERConstant load exercise training N
Exercise training and ambient air breathing
OTHERConstant load exercise training H
Exercise training and hypoxic breathing
OTHERHypoxic conditioning at rest
Hypoxic breathing at rest
OTHERNormoxic conditioning at rest
Normoxic breathing at rest (placebo)
Sponsors
University Hospital, Grenoble
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* BMI between 27 and 35 kg/m² * Physical activity \<2 hours/week * No chronic disease or treatment able to interfere with inflammation and metabolic perturbatiosn associated with obesity
Exclusion criteria
* Diabetes mellitus treated with insulin * Auto-immune or inflammatory diseases requiring long term therapy * Unstable dysthyroidism * Bariatric surgery within the past 18 months * Tumoral, inflammatory, infectious, cardiac, respiratory, kidney, digestive disease * Untreated sleep apnea
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximal exercise capacity | 8 weeks | Maximal oxygen consumption during an incremental exercise test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Metabolic status | 8 weeks | Blood lipids, glycemia, HOMA index, oxydative stress and inflammatory status |
| Body composition | 8 weeks | MRI fat free mass and adipose tissue measurements |
| Blood pressure | 8 weeks | 24 h ambulatory blood pressure mesurement |
| Vascular function | 8 weeks | Post-ischemic hyperemia (Endo-Pat) and pulse wave velocity |
| Physical activity | 8 weeks | Spontaneous physical activity measured by accelerometry |
Countries
France
Contacts
Primary ContactSamuel Verges, PhD
Backup ContactPatrice Flore, PhD
Outcome results
None listed