Heart Failure
Conditions
Keywords
NSAIDs, Heart failure, Acute kidney injury
Brief summary
The purpose of this study is to evaluate whether non-steroidal anti-inflammatory drugs (NSAIDs) were associated with acute kidney injury (AKI) in patients with heart failure. In addition, the investigators would like to assess the risk of admission for acute decompensated heart failure following exposure to NSAIDs within 30 days.
Interventions
None listed
Sponsors
National Taiwan University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patient's age was more than 20 years old 2. Diagnosis of heart failure 3. With prescription of NSAIDs (only oral and intravenous form are included)
Exclusion criteria
1. With prescription of NSAIDs administered by topical use 2. Patient was pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in serum creatinine at 1 month | Baseline and 1 month | We collect not only patient's baseline serum creatinine level (defined as the median value of the previous-six-months serum creatinine), but also serum creatinine level on the detecting day (defined as the most recent day from index date we detecting the serum creatinine). Acute kidney injury is defined as the absolute increase in the serum creatinine concentration of ≥0.3 mg/dL from baseline; or a percentage increase in the serum creatinine concentration of ≥50 percent. |
Secondary
| Measure | Time frame |
|---|---|
| Admission for acute decompensated heart failure | 1 month after exposure to NSAIDs |
Countries
Taiwan
Contacts
Primary ContactChii-Ming Lee
Backup ContactPo-Lin Chen
Outcome results
None listed