Elective Valvular Cardiac Surgery
Conditions
Brief summary
The level of four biomarkers will be measured in the patients' plasma after induction of anaesthesia. There biomarkers are NT-ProBNP, ST2, Galectin-3 and GDF-15. The level of these marker will then be correlated with early (30 days) and late (one year) patients' prognosis and with functional recovery (MLHFQ score).
Interventions
PROCEDURECardiac valve surgery
Aortic or mitral valve replacement/repair performed in isolation of in addition to coronary artery bypass graft(s).
Sponsors
University of Liege
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years * Elective/urgent aortic or mitral valve surgery in isolation or combined with CABG
Exclusion criteria
* Emergency or salvage surgery * Inability to consent * Previous cardiac surgery * Stage IV or V CDK (GFR ≤ 30 ml/min) or dialysis * Active Endocarditis * Liver cirrhosis * Chronic atrial fibrillation * Pacemaker
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Composite primary outcome | 30 days | In hospital or 30-days mortality or inotropic support during more than 48 hours or lengthy of ICU stay longer than 5 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Post-operative AKI | 48 hours | AKIN stage during the first 48 hours |
| Ejection fraction | 1 year | EF at 30 days and at 1 year |
| NYHA | 1 year | NYHA class at 30 days and at 1 year |
| ICU readmission | 30 days | — |
| reshopitalisation | 1 year | hospital admission for cardiac failure during the first postoperative year |
| one year mortality | 1 year | mortality during the first postoperative year. |
| MLHFQ | 1 year | Minnesota living with heart failure questionnaire at 30 days and at 1 year |
Countries
Belgium
Contacts
Primary ContactGregory A Hans, MD, PhD
Outcome results
None listed