A Prospective Cohort Study of Aged People for Chronic Diseases

A Hospital-based Prospective Cohort Study With Aged People to Elucidate Predictive Factors Including Muscle and Fat Mass for Chronic Diseases and Mortality

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02640872

Acronym

HAPPY

Enrollment

1000

Registered

2015-12-29

Start date

2015-07-31

Completion date

2021-03-15

Last updated

2021-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging, Sarcopenia

Keywords

sarcopenia, sarcopenic obesity, osteoporosis, fracture, cardiovascular disease, mortality

Brief summary

This study is a hospital-based, prospective cohort study to elucidate the predictive factors including muscle and fat mass for chronic diseases and mortality in elderly persons aged 60 years and older.

Detailed description

This study is a hospital-based, prospective cohort study to elucidate the predictive factors among anthropometric and biochemical parameters and body composition information for chronic diseases including diabetes mellitus, myocardial infarction, stroke, osteoporosis, fracture, and cognitive dysfunction, and mortality in elderly persons aged 60 years and older.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Aged 60 years and older * Capable of communication with the research team * Provided written informed consent

Exclusion criteria

* Age \< 60 years * active malignancy * uncompensated liver cirrhosis * ESRD * severe cognitive impairment which cannot communicate with the research term

Design outcomes

Primary

Measure	Time frame
Alll cause mortality	9 years

Secondary

Measure	Time frame
Incidence of major adverse cardiac event including nonfatal myocardial infarction, nonfatal stroke, and unstable angina	9 years
Incidence of frailty defined by the Korean Fraility Index	9 years
Cardiometabolic mortality	9 years
Incidence of cognitive dysfunction measured by minimental status examination	9 years
Development of sarcopenia defined by the Foundation for the National Institutes of Health (FNIH) criteria	9 years
Incidence of osteoporotic fracture	9 years

Countries

South Korea

Outcome results