Cluster Headache, Addictions and Vascular Function

Cluster Headache (CH), Addictions and Vascular Function

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02640105

Acronym

CHAD

Enrollment

Registered

2015-12-28

Start date

2014-06-25

Completion date

2016-06-10

Last updated

2022-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cluster Headache

Brief summary

Cluster headache (CH) is one of the most painful primitive headaches. Developments in neuroimaging have demonstrated activation of the ipsilateral hypothalamic and orexinergic system, which is similar in patients with addictions. CH has strong links to the vascular system but there is no study measuring endothelial function in CH sufferers.

Detailed description

Several studies have shown an association between Cluster headache (CH) and smoking. However, no data exists on the link between CH and other addictions, and impact of these addictions on clinical characteristics of the disease. In addition, despite the strong biological link between CH and the vascular system, systematic investigations about vascular functions in CH patients are lacking. This will be a prospective cohort study of 150 patients with CH, conducted in the Headache Center in Bordeaux, France.

Interventions

OTHERNeurological clinical examination

Diagnostic and description of cluster headache

OTHERPsychological clinical examination

Scale and questionnaires

OTHERQuestionnaires

Psychopathological and cognitive questionnaires

OTHERBlood sample

Blood sample for DNA collection

OTHEREndothelial function measurement

Endothelial function will be measured with a noninvasive Peripheral Arterial Tone (PAT) signal technology using the EndoPAT device

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Presenting a chronic or episodic cluster headache diagnosed according to the International Classification of Headache Disorders (ICH-D III) criteria, in active or inactive phase.

Exclusion criteria

* Other primary headaches * Subjects without social insurance

Design outcomes

Primary

Measure	Time frame
Duration of active periods of cluster headache	Day 0 (Inclusion visit)
Number of active periods	Day 0 (Inclusion visit)
Duration of cluster headache	Day 0 (Inclusion visit)
Severity of attacks	Day 0 (Inclusion visit)

Secondary

Measure	Time frame	Description
Existence of an addiction	Day 0 (Inclusion visit)	—
Severity of Addiction	Day 0 (Inclusion visit)	—
Reactive Hyperemic Index (RHI)	Day 0 (Inclusion visit)	Endothelial function measurement

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026