Pregnancy Rate by HCG Administration Versus Urinary LH Surge Method in Patients Undergoing IUI

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02638285

Enrollment

Registered

2015-12-23

Start date

2009-01-31

Completion date

Unknown

Last updated

2015-12-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy

Brief summary

To compare pregnancy rate by Human Chorionic Gonadotropin (HCG) administration and urinary Luteinizing Hormone (LH) surge method for insemination in patients undergoing Intrauterine Insemination (IUI) at Montaserieh infertility center. The present study comprised 309 infertile women candidate for IUI, randomly divided into LH surge and HCG groups (assign the number for each patient, odds number for LH and even number for HCG group). All patients were subjected to baseline ultrasound and received clomiphene citrate before undergoing serial transvaginal sonography. LH was measured using LH kit when 2-5 follicles (18-20 mm) appeared in LH surge group, and if positive, IUI was performed after 24 hours. In HCG group, the patients received HCG 1000 units and underwent IUI after 36 hours. The pregnancy rate was then compared in LH and HCG groups.

Interventions

DRUGLH

DRUGHCG

DRUGClomiphene

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Healthy volunteers

Yes

Inclusion criteria

* infertile women candidate for IUI

Exclusion criteria

* women with negative urinary LH surge which required HCG administration, * those with more than 5 follicles who had to use LH kit and not receive HCG to avoid ovarian hyperstimulation.

Design outcomes

Primary

Measure	Time frame
pregnancy rate	Two weeks after IUI

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026