Open-angle Glaucoma
Conditions
Keywords
matrix metalloproteinase 13, tissue inhibitor of metalloproteinases 3, calcium-sensing receptor, trabecular meshwork, open-angle glaucoma
Brief summary
This study was to assess the distinct expression of matrix metalloproteinase 13,tissue inhibitor of metalloproteinases 3, and calcium-sensing receptor, in human trabecular meshwork between normal and glaucomatous eyes.The expressions of matrix metalloproteinase 13, tissue inhibitor of metalloproteinases 3 and calcium-sensing receptor in the trabecular meshwork tissues were examined by streptavidin-peroxidase immunohistochemical staining method and western blot, and histological changes of trabecular meshwork were studied by Hematoxylin and Eosin staining.
Interventions
PROCEDUREtrabeculectomy
Sponsors
Lv Yingjuan
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* intraocular pressure greater than 22 mmHg with two or more medications * wide anterior chamber angle * glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect * visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry
Exclusion criteria
* the presence of any secondary form of glaucoma including exfoliation syndrome or a history of ocular trauma, etc
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the expressions of matrix metalloproteinase 13 and calcium-sensing receptor | one hour after operation |
Secondary
| Measure | Time frame |
|---|---|
| histological changes of trabecular meshwork | one hour after operation |
Countries
China
Outcome results
None listed