Evaluation of the Efficacy of Restylane Silk in the Treatment of Cheek Fold (Radial Smile Lines)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02636894

Enrollment

Registered

2015-12-22

Start date

2016-03-31

Completion date

2016-08-31

Last updated

2019-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Smile Lines

Brief summary

Filler study for smile lines in cheek folds

Interventions

DEVICERestylane Silk

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Male or female between 21-65 years of age * Willing to comply with study visits and procedures * Willingness to refrain form surgical, laser, or injectable treatments in cheek region during study

Exclusion criteria

* History of trauma, acne scarring, burns, or other changes to skin in treatment area * Use of botulinum toxin in the lateral cheeks/perioral region in past 6 months * Use of injectable fillers in the lateral cheeks/perioral within last 2 years * History of facelift in the last year * History of facial nerve palsy

Design outcomes

Primary

Measure	Time frame	Description
Evaluation of the Efficacy of Restylane Silk in the Treatment of Cheek folds (Radial Smile Lines)	6 months	Improvement of subjects based on 5 point global aesthetic scale (GAIS)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026