Osteoporosis
Conditions
Brief summary
Bone responds according to the load placed on it. In this study, investigators want to know if exercise that loads the body in exercises, like walking or jogging (Ground Reaction Forces: GRF), affects bone differently than exercises that load the joints, like weight lifting (Joint Reaction Forces: JRF). Participants will exercise at least 3 times a week for 6 months. Measures of bone strength and mass, muscular strength, and aerobic fitness will be taken at the beginning and the end of the 6 month program. Period blood samples will be taken for future analysis of blood markers.
Interventions
BEHAVIORALGround Reaction Forces
6 month exercise program that loads the body via gravitational forces.
BEHAVIORALJoint Reaction Forces
6 month exercise program that loads the body via loading the joints.
Sponsors
VA Eastern Colorado Health Care System
University of Colorado, Denver
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* non-smoker * in generally good health * not physically active (less than 60 minutes of purposeful exercise/week) * able to travel to the exercise facility a minimum of 3 times/week
Exclusion criteria
* use of glucocorticoids * abnormal resting EKG * angina and/or evidence of acute myocardial ischemia during a treadmill test * resting blood pressure above 150 mmHg systolic of 90 mmHg diastolic * anti-resorptive drug use in the last 2 years * initiation of treatments that could impact bone metabolism (diuretics, hormones, bine anabolic agents) in the prior 6 months * dual-energy x-ray absorptiometry (DXA) t-score \<+ -2.5 at the femoral neck and/or lumbar spine * serum vitamin D concentration \<20 ng/mL * uncontrolled thyroid disease * any contraindications to regular exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Volumetric Bone Mineral Density (vBMD) | Baseline and 6 month | Measured via quantitative computed tomography (QCT) |
| Change in Areal Bone Mineral Density (aBMD) | Baseline and 6 month | Measured via dual-energy x-ray absorptiometry (DXA) |
| Change in Bone Strength | Baseline and 6 month | Measured via finite element analysis (FEA) from QCT |
Secondary
| Measure | Time frame |
|---|---|
| Change in 1-Repetition Maximum (1RM) | Baseline and 6 month |
| Change in Maximal Oxygen Uptake (cardiovascular fitness) | Baseline and 6 month |
Countries
United States
Outcome results
None listed