Preterm Premature Rupture of Membranes
Conditions
Keywords
vitamin c, Preterm Premature Rupture of Membranes
Brief summary
To study the association between maternal serum vitamin C concentration in women with preterm premature rupture of membranes (PPROM) and women without PPROM.
Detailed description
The micronutrient vitamin C is an effective water soluble antioxidant that scavenges several reactive oxygen species, thus reducing oxidative stress, It also acts as an enzymatic cofactor to the enzymes lysyl hydroxylase and prolyl hydroxylase, which is required for synthesis of hydroxyproline and hydroxylysine, Collagen requires hydroxyproline bridges across the triple helix to provide stability to it, Ascorbic acid also causes down regulation of the metalloproteinase-2 and biosynthesis of collagen where it is required for the formation of triple helical structure of collagen. Thus, ascorbic acid participates in the equilibrium between synthesis and degradation of collagen and this may be critical in reducing the occurrence of preterm PROM.
Interventions
None listed
Sponsors
Ain Shams Maternity Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
* Singleton pregnancies * Gestational age between 28-37 weeks * Rupture of membranes will be diagnosed by history, sterile speculum examination to confirm fluid leakage from the cervical canal
Exclusion criteria
* Patients with multiple pregnancies * Smoker * Polyhydramnios * Maternal diseases such as: anemia, diabetes, UTI, RTI and vaginal infection * History of PPROM in previous pregnancies * Evidence of chorioamnionitis in current pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| relation between serum vitamin C concentration and PPROM | 6 months |
Contacts
Primary ContactMohamed Hu Mostafa, MD
Backup ContactMohamed Hu Mostafa, MD
Outcome results
None listed