Effect of Loading of Midazolam or Dexmedetomidine on Hemodynamics

Hemodynamic Change Between Loading of Dexmedetomidine or Midazolam as a Sedative Agents During Knee Arthroscopy

Status

Withdrawn

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02634021

Enrollment

Registered

2015-12-17

Start date

2015-07-31

Completion date

2018-07-31

Last updated

2021-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Injuries

Brief summary

Loading dose of dexmedetomidine is related hemodynamic instability such as bradycardia and hypertension.

Detailed description

The investigators hypothesized substitution of loading of dexmedetomidine for midazolam could reduce hemodynamic instability during spinal anesthesia for knee arthroscopy.

Interventions

DRUGdexmedetomidine group

intravenous loading of dexmedetomidine for 1 mcg/kg

DRUGmidazolam group

intravenous loading of midazolam for 0.1 mg/kg

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients who were planned to undergo knee arthroscopy under spinal anesthesia

Exclusion criteria

* age \< 20 years * underlying heart, liver or kidney disease * hypersensitivity to midazolam or dexmedetomidine

Design outcomes

Primary

Measure	Time frame
change of heart rate	from 1 minute before anesthesia to 1 hr after anesthesia

Secondary

Measure	Time frame
change of bispectral index	from 1 minute before anesthesia to 1 hr after anesthesia

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026