Respiratory Insufficiency
Conditions
Keywords
Nasal High Flow, CPAP, airway pressure, newborn
Brief summary
Nasal High Flow (NHF) and CPAP are established forms of respiratory support in neonates and often produce similar clinical outcomes. The aim of the study was to investigate airway pressure during NHF and CPAP in neonates.
Detailed description
Methods: A physiological study which measured pressure intra-nasally with micro (750 µm) pressure probes (Millar, USA) in 10 (5M / 5F) healthy newborns with mean gestation age 37.18 (SD 1.29) wk and mean birth weight of 2414 (SD 503.13) g. NHF was applied at 8 L/min (AIRVO 2) through smaller (OPT 314) and larger (OPT 316) Optiflow nasal cannula; CPAP 5 cmH20 was produced by a Bubble CPAP system and nasal mask interface at constant flow 8 L/min (Fisher & Paykel Healthcare, NZ). Values are expressed in cmH20 as means and standard deviations (SD).
Interventions
DEVICENHF small cannula
NHF 8 l/min by Airvo 2 by small cannula
DEVICENHF big cannula
NHF 8 l/min by Airvo 2 by large cannula
DEVICECPAP
Nsal CPAP 5cm H2o by face mask
Sponsors
Fisher and Paykel Healthcare
Research Center of Maternal and Child Health Protection, Armenia
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Days to 3 Days
Healthy volunteers
Yes
Inclusion criteria
* Healthy term newborns
Exclusion criteria
* Newborns with any medical problems after birth * Absent of parents consents
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Upper airway pressure generated by NHF compared to CPAP | Up to 1 hour | Pressure in upper airways |
Countries
Armenia
Outcome results
None listed