Disorders of Consciousness
Conditions
Brief summary
The purpose of this study is to evaluate whether personalized stimulations can improve the detection of electrophysiological signs of awareness in patients with disorders of consciousness.
Interventions
Sponsors
Centre Hospitalier Universitaire de Besancon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* patients in a vegetative state or a minimally conscious state * agreement from families
Exclusion criteria
* patients with akinetic mutism or locked-in syndrome * patients in a coma * patients with damages in the inner or middle ear * contraindication to a high-density electroencephalography exam
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants showing differences of electrophysiological activity after personalized but not standard stimulation protocols | standard stimulations: 28 days after recruiting patients | Depending of the personalized stimulation protocol, the differences of electrophysiological activity can the presence of event-related potentials (N100, mismatch negativity, P300, etc.) or alterations of neural oscillations. The personalized stimulation protocol will be chosen according to the families' feeling of a presence. |
Contacts
Primary ContactDamien Gabriel, PhD
Outcome results
None listed