Aging
Conditions
Brief summary
Normal aging is associated with gradual cognitive declines. These mild neurocognitive disturbances affect daily functioning, health status, and quality of life, and likely account for the roughly $2.9 billion lost by the elderly each year to fraud. The goal of this project is to compare two different 8-week training programs to promote successful neural and cognitive aging. Changes in neural structure and cognitive function will be assessed in a cohort of older adults, as well as the long-term stability of these changes over 24 months.
Detailed description
Normal aging is associated with gradual cognitive declines. These mild neurocognitive disturbances affect daily functioning, health status, and quality of life, and likely account for the roughly $2.9 billion lost by the elderly each year to fraud. People are paying millions out of pocket for cognitive training programs like Lumosity to stave off these declines. These cognitive decreases have been strongly associated with normal age-dependent declines in neural structure and function, including cortical thickness decreases (approximately 0.02 mm per decade) across most of the cortical mantle, as well as decreases in the volume of the hippocampus (approximately 1-2% annually), white matter microstructure, and functional connectivity across the brain. Life expectancy is increasing and so identifying interventions that can be widely implemented and that can slow or reverse normal cognitive decline are clinical and public health priorities. Some training programs can improve cognitive performance in cognitively normal older adults, and gains are maintained post training. The investigators hypothesize that different techniques to boost cognition likely works through different neural mechanisms, and thus may provide different cognitive benefits. The goal of this project is to compare two different 8-week training programs to promote successful neural and cognitive aging. Changes in neural structure and cognitive function will be assessed in a cohort of older adults, as well as the long-term stability of these changes over 24 months.
Interventions
BEHAVIORALCognitive training program
8 week cognitive training program
Sponsors
National Institutes of Health (NIH)
National Institute on Aging (NIA)
Massachusetts General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* 65-80 years of age * Right-handed
Exclusion criteria
1. Lifetime history of schizophrenia or psychosis. Any other Axis I diagnosis in the past 12 months. 2. Subjects must not endorse suicidality, homicidality or self-destructive acts or urges as assessed through a structured clinical interview (SCID) 3. History of seizure or significant head trauma (i.e., extended loss of consciousness, neurological sequelae, or known structural brain lesion). 4. Neurological or medical conditions that would interfere with study procedures or confound results, such as conditions that alter cerebral blood flow or metabolism. 5. Use of psychotropic medications within 12 months prior to study. 6. Daily use of any medication that alters neural metabolism or blood flow. 7. Any concurrent psychotherapy. 8. Having taken no more than 8 meditation classes (or related practices such as yoga, Tai Chi, or Chi Gong) of any kind in the past 6 months, or more than 15 classes in the past 12 months. 9. Pregnancy. 10. Metallic implants or devices contraindicating magnetic resonance imaging. 11. Claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in brain structure | 8 weeks | Gray matter structure will be assessed before and after the 8 week programs. |
| Change in brain activity during a memory test | 8 weeks | Brain activity during a memory task will be assessed before and after the 8 week programs. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood markers | baseline, 8 weeks, 12 and 24 months | Blood will be collected at baseline, 8 weeks, 12 and 24 months. This will be used to assess changes in various biomarkers that are known to change with aging. |
| Change in cognition | 2 years | Participants will complete a series of memory and attention tests at 6 time-points: baseline, 2 months, 6 months, 12 months 18 months and 24 months. |
Countries
United States
Outcome results
None listed